WebNov 20, 2024 · The basic process of autophagy. Cells need integrated degradation mechanisms, such as autophagy and the ubiquitin-proteasome system (UPS), to remove intracellular waste generated during metabolism or aging [].Unlike the UPS, the process of autophagy is mediated by the formation and maturation of multiple membrane vesicles, … WebColorectal cancer (CRC) is the most common intestinal malignancy, and nearly 70% of patients with this cancer develop metastatic disease. In the present study, we synthesized a novel compound, termed N-(3-(5,7-dimethylbenzo [d]oxazol-2-yl)phenyl)-5-nitrofuran-2-carboxamide (compound 275#), and found that it exhibits antiproliferative capability in …
Glutamine, MTOR and autophagy: a multiconnection …
WebCancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell … WebNational Center for Biotechnology Information grafton base hospital
Novel role of miR-133a-3p in repressing gastric cancer growth …
WebMar 15, 2024 · During glutamoptosis, the activation of MTORC1 by αKG production through glutaminolysis (and perhaps also by other inputs from glutamine) induces the autophagy-dependent accumulation of SQSTM1/p62. In the absence of other amino acids, SQSTM1/p62 induces CASP8 cleavage in a BAX-dependent manner, leading to cell death. Web摘要： 目的 利用单细胞测序技术寻找喉癌细胞糖酵解和谷氨酰胺代谢相关中小分子靶向药物可能的靶基因。方法 利用r语言对既往单细胞测序的结果重分析,对细胞进行tsne分类,对代谢相关基因在喉癌各细胞亚群中的表达进行分析。结果 喉癌细胞糖酵解过程中可能成为小分子代谢药物作用靶点的基因 ... WebJun 9, 2015 · Glutaminolysis and autophagy in cancer Victor H. Villar 1,2,3 , Faten Merhi 2,3 , Mojgan Djavahe ri-Mergny 2,3,5 and Raúl V. Durán 1,2,3,4 1 Institut Européen de Chimie et Biol ogie, 2 Rue ... grafton base hospital address