Downregulated meaning
WebFeb 3, 2024 · Down-regulation is a term that scientists use to describe the process of reducing or suppressing the body's response to specific stimuli. When used with regard … WebThe simple answer is that we feel it is a gross oversimplification to call a pathway as “upregulated” or “downregulated”. In most cases, a call of this nature would be …
Downregulated meaning
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WebApr 9, 2024 · Definition of 'downregulate' downregulate noun to decrease the sensitivity to a drug or other chemical by reducing the number or density of receptors on cell surfaces … WebDownregulation Definition. (genetics) The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity.
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus. The complementary process that involves increases of such components is called upregulation. An example of downregulation is the cellular decrease in the expression of a specific receptor in … WebOne would call a gene "donw-regulated" (in response to the treatment) when the expression under treatment conditions is lower than under control conditions.
WebApr 13, 2024 · The observation that an increase in cell culture density does not suppress the expression of Tnfsf9, a gene downregulated during photoreceptor development, may indicate that multiple extrinsic ... Downregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. Such an epigenetic alteration can cause expression of the RNA or protein to no longer respond to an external stimulus. This occurs, for instance, during drug addiction or progression to cancer . See more In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an … See more Elevated levels of the hormone insulin in the blood trigger downregulation of the associated receptors. When insulin binds to its receptors on … See more DNA damage appears to be the primary underlying cause of cancer. If accurate DNA repair is deficient, DNA damages tend to accumulate. Unrepaired DNA damage can increase mutational errors during DNA replication due to error-prone translesion synthesis. … See more All living cells have the ability to receive and process signals that originate outside their membranes, which they do by means of proteins called receptors, often located at the cell's surface imbedded in the plasma membrane. When such signals interact with a … See more Family-based, adoption, and twin studies have indicated that there is a strong (50%) heritable component to vulnerability to substance abuse … See more • Regulation of gene expression • Desensitization (medicine) • Addiction • Cocaine See more • Sherwood, L. (2004). Human Physiology From Cells to Systems, 5th Ed (p. 680). Belmont, CA: Brooks/Cole-Thomson Learning • Wilmore, J., Costill, D. (2004). Physiology of Sport … See more
Webdown-reg·u·la·tion. ( down-reg'yū-lā'shŭn ), Development of a refractory or tolerant state consequent on repeated administration of a pharmacologically or physiologically active substance; often accompanied by an initial decrease in affinity of receptors for the agent and a subsequent diminution in the number of receptors.
WebJul 15, 2024 · Gender affects cancer susceptibility. Currently, there are only a few studies on Y chromosome-linked long noncoding RNAs (lncRNAs), and the potential association between lncRNAs and cancers in males has not been fully elucidated. Here, we examined the expression of testis-specific transcript Y-linked 15 (TTTY15) in 37 males with non … phlebitis scoringWebJun 29, 2024 · The expression of KLRG1, BTK, CCR2 and SCML4 was significantly downregulated in LUAD tissues compared to normal controls. Knockdown of KLRG1 promoted the proliferation of A549 and H1299 tumor cells. And low expression of these four factors was associated with unfavorable overall survival in patients with LUAD. phlebitis specialtyWeba decrease in sensitivity, through overexposure, to a drug or other chemical caused by a reduction in the number or density of receptors on cell surfaces. phlebitis sole of foot