WebApr 7, 2024 · TGFβ and CTGF promote fibrosis by NOTCH signaling pathway activation. Therefore, TGFβ1 and CTGF were used to activate NOTCH signaling in vitro. First, human healthy meniscus cells were treated with TGFβ1, NOTCH3 siRNA (or HEYL siRNA), or TGFβ1+NOTCH3 siRNA (or HEYL siRNA). The COL1A1 RNA levels were detected by … WebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, …
Role of CTGF gene promoter methylation in the development of …
WebJan 12, 2011 · San Francisco, CA - January 12, 2011. FibroGen, Inc. today announced initiation of an open-label phase 2 study to evaluate the safety, tolerability, and efficacy of FG-3019, a human monoclonal antibody against connective tissue growth factor (CTGF), in individuals with idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fatal lung … WebMay 19, 2024 · Among those, CTGF is a key mediator of ECM production, leading to proliferation of lung fibroblasts and progression of lung fibrosis. CTGF does not behave like a traditional growth factor or ... cannibal corpse the bleeding album cover
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WebMay 28, 2024 · CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis. CTGF was found to be overexpressed in fibrotic lesions in major organs, including the lung, … WebApr 11, 2024 · Nevertheless, clinical observations have shown that CTGF expression in the sera and fibrotic liver tissues of CHB patients is upregulated. A strong correlation … WebFeb 25, 2024 · FG-3019 (pamrevlumab) is a human monoclonal antibody (mAb) against CTGF that has shown efficacy in a randomized, placebo-controlled phase 2 clinical trial in subjects with idiopathic pulmonary fibrosis , as well as in phase 2 clinical trials for treatment of pancreatic cancer and Duchenne muscular dystrophy (NCT02210559 and … cannibale danielle thiery