WebMay 20, 2024 · The median (range) age was 71.5 (50–80) years old, and 11/12 (91.7%) were defined as the CHAARTED high-volume group. Eleven (91.7%) had 3 or more bone metastases, and 4 (33.3%) had visceral metastasis. The initial dose of docetaxel was 70 or 75 mg/m 2 and was scheduled to be administered for up to 6 courses every 3 or 4 weeks. WebJun 9, 2014 · However, a patient with one large bony metastatic lesion in their hip would not qualify as having high-volume disease based on the authors’ definition; however, he or she may benefit from docetaxel despite their metastases being classified as low-volume. Overall, the CHAARTED trial is an important, positive study that may change our ...

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WebDec 1, 2024 · Defined as the presence of two of the three following factors: GS ≥8, ≥3 bone lesions, measurable visceral metastasis. The number (percentage) of patients who … WebJul 2, 2024 · We then compared the prognosis between CHAARTED criteria with a high volume and that with a low volume. CHAARTED high-volume disease was defined as … tousled hair salon marlborough ct

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WebNational Center for Biotechnology Information WebHigh-volume disease definition (modified CHAARTED) included: 1) visceral metastases and ≥1 bone lesion, or 2) ≥4 bone lesions, with ≥1 outside of the vertebral column or pelvis. Low volume disease definition: (presence of) bone lesions not meeting the high-volume definition. At baseline, 63% of patients had high-volume and 37% had low ... WebApr 2, 2024 · ADT Plus Docetaxel. For men with metastatic non-castrate prostate cancer with high-volume disease (HVD) per CHAARTED who are candidates for treatment with chemotherapy, the addition of docetaxel to ADT should be offered (Type: evidence based, benefits outweigh harms; Evidence quality: high; Strength of recommendation: strong for … poverty as structural violence